Using Date Seed Powder Nanoparticles and Infusion as a Sustainable Source of Nutraceuticals
Amany Alsayed Salama,
Naglaa Mohamed Ismael,
Mervat Mostafa Megeed
Issue:
Volume 7, Issue 3, May 2019
Pages:
39-48
Received:
1 August 2019
Accepted:
22 August 2019
Published:
5 September 2019
Abstract: Egypt is the world's largest date producing country. Different functional foods pertaining to date seeds were attempted before. Phenolic phytochemicals are not well absorbed in gastrointestinal tract, which results in lower bioactivity. Nanotechnology helps to resolve poor oral bioavailability. Aim was to evaluate the in-vivo anti-inflammatory properties of date seed powder (DSP) nanoparticles (NPs) and infusion in rats fed a high fat diet (HFD). Twenty five Wistar rats were distributed among five groups; I (control), II (on HFD), III (on HFD and DSPNP1 1:5), IV (on HFD and DSPNP2 2:3), and V (on HFD and DSP infusion 1g/kg/day). Blood samples were tested for C-reactive protein (CRP), Serum amyloid-A (SAA), total cholesterol, HDL, albumin, creatinine, and some primary biochemical parameters. HFD induced significant elevations in cholesterol and inflammatory markers as compared to the controls; while, HDL, ALT, AST, creatinine and albumin showed no change in all rats. In all DSP treatment groups, total cholesterol levels were reduced significantly. Both DSP NPs and infusion caused significant decrease in CRP and SAA levels. DSP NPs exhibited the same anti-inflammatory effects as their free counterparts. Using polyvinyl alcohol NPs of DSP in a wt/wt ratio of 2 PVA: 3 DSP; resulted in an acceptable particle size and physicochemical properties.
Abstract: Egypt is the world's largest date producing country. Different functional foods pertaining to date seeds were attempted before. Phenolic phytochemicals are not well absorbed in gastrointestinal tract, which results in lower bioactivity. Nanotechnology helps to resolve poor oral bioavailability. Aim was to evaluate the in-vivo anti-inflammatory prop...
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Effect of Ingesting Resistant Maltodextrin on Postprandial Hyperlipidemia Induced by Fructose in Young Women
Kaori Kuzawa,
Akihiro Yoshida,
Ikuko Tsukamoto,
Masaaki Tokuda,
Michitaka Naito
Issue:
Volume 7, Issue 3, May 2019
Pages:
49-55
Received:
2 August 2019
Accepted:
24 August 2019
Published:
19 September 2019
Abstract: Aim: Our previous study demonstrated that the ingestion of fructose with fat exacerbated and delayed postprandial lipid metabolism (J Atheroscler Thromb 2013; 20: 591). Herein, we investigated the effect of ingesting a water-soluble dietary fiber, resistant maltodextrin (RMD), which has been reported to be effective for ameliorating postprandial glycemia and lipidemia, on fructose-induced postprandial hyperlipidemia in healthy young women. Methods: Healthy young Japanese women with apolipoprotein E3/3 phenotype were enrolled. They underwent 4 test trials in a randomized crossover design: fat cream (0.35 g/kg of fat; F trial), fat cream with RMD (5 g; FR trial), fat cream with fructose (0.5 g/kg; FFr trial), and fat cream with fructose and RMD (FFrR trial). Blood samples were taken before (0) and at 0.5, 1, 2, 4, and 6 h after ingestion. Results: The serum glucose and insulin concentrations peaked at 0.5 h in the FFr and FFrR trials, and no difference was observed between these trials. There was no increase in glucose concentration in the F or FR trials. The serum triglyceride and apolipoprotein B48 concentrations peaked at 4 h in all trials. In the F and FR trials (but not in the FFr and FFrR trials), the serum triglyceride concentration returned to the fasting level at 6 h. In all trials, the apolipoprotein B48 concentration did not return to baseline at 6 h. Conclusion: Co-ingestion of RMD did not significantly inhibit fructose-induced postprandial hyperlipidemia.
Abstract: Aim: Our previous study demonstrated that the ingestion of fructose with fat exacerbated and delayed postprandial lipid metabolism (J Atheroscler Thromb 2013; 20: 591). Herein, we investigated the effect of ingesting a water-soluble dietary fiber, resistant maltodextrin (RMD), which has been reported to be effective for ameliorating postprandial gl...
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