Effects of Ingesting Amino Acids Simultaneously with Glucose and Fat on Postchallenge Metabolism in Healthy Young Women:: Science Publishing Group

Effects of Ingesting Amino Acids Simultaneously with Glucose and Fat on Postchallenge Metabolism in Healthy Young Women

Yukino Morita, Natsuko Ichikawa, Kayo Ootani, Michitaka Naito

School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan

Journal of Food and Nutrition Sciences, Volume 11, Issue 4, July 2023

Pages: 132-139

Received: Jul. 18, 2023

Accepted: Aug. 07, 2023

Published: Aug. 15, 2023

DOI: 10.11648/j.jfns.20231104.14

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Abstract

Aim: To investigate the effects of ingesting amino acids simultaneously with glucose and fat on postchallenge glycemia and lipidemia. Methods: The subjects were eleven healthy young Japanese women (age 21.1 ± 0.1 y). In each session, the subjects ingested one of three beverages in a randomized crossover design. Materials used were an amino acid mixture (Amizet B™, 0.6 g/kg of body weight, 60 mg/kg as amino acids), glucose (1 g/kg of body weight), and fat cream (OFTT™ cream, 1 g/kg of body weight, 0.35 g/kg as fat). The three beverages were as follows: an amino acid mixture (A trial), glucose and fat cream (GF trial), or a mixture of glucose, fat cream, and amino acids (GFA trial). Venous blood samples were obtained before (0) and 0.5, 1, 2, and 3 h after ingestion in the A trial and 0, 0.5, 1, 2, 4, and 6 h after ingestion in the GF and GFA trials. Results: The ingestion of amino acids alone (without glucose) slightly stimulated the secretion of insulin, and both insulin and glucagon levels significantly increased without changes in the glucose level. Co-ingestion of fat with glucose reduced the glucose rise, and the addition of amino acids suppressed the reduction in the blood glucose rise. There were no significant effects of the ingestion of amino acids simultaneously with glucose and fat on the lipid or lipoprotein metabolism as compared to the ingestion of glucose and fat. Conclusion: Co-ingestion of amino acids with glucose and fat increased the glucose level compared to the ingestion of glucose and fat, probably by suppressing insulinotropic and glucagon-inhibitory effects. We conclude that the ingestion of amino acids simultaneously with glucose and fat inhibits postchallenge glucose metabolism but does not significantly influence lipid and lipoprotein metabolism as compared to the ingestion of glucose and fat.

Keywords

Amino Acids, Postchallenge Glycemia, Postchallenge Lipidemia, Young Women, Insulin, Glucagon, GIP, GLP-1

To cite this article

Yukino Morita, Natsuko Ichikawa, Kayo Ootani, Michitaka Naito. (2023). Effects of Ingesting Amino Acids Simultaneously with Glucose and Fat on Postchallenge Metabolism in Healthy Young Women. Journal of Food and Nutrition Sciences, 11(4), 132-139. https://doi.org/10.11648/j.jfns.20231104.14

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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